Image of the Quarter
Strongly amplified HER2 FISH - 'Mouse-over' for arrows:


strongly amplified HER2 FISH

The green arrow points to a clump of HER2 signals (pink/red in colour).
The blue arrow points to one of two CEP17 signals (faint blue dots) in the cell.
Most of the cells in this image are diploid & many cells show two clumps of HER2 signals.


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Update:


The site is undergoing a substantial upgrade and I apologise for any inconvenience caused. In the first instance I will be starting with the home page to improve its rendering on different sized devices e.g. mobiles or tablets. I am then going to start working through the content page by page upgrading and updating the images and text. I have now upgraded the section on benign microcalcification and hopefully further upgrades will be simpler having solved a number of important coding problems.

The Image of the Quarter is unchanged - a really lovely example of amplified HER2 FISH.

The site is now over ten years old - it went live in February/March 2006. I am grateful to all the vistors, colleagues and trainees who help to encourage its further growth and development. Visitor numbers are steady at about 1,000 a month. The most frequently accessed pages remain broadly unchanged from previous years.

I am absolutely delighted to continue to work with colleagues on the Sloane Project. We have previously updated the ADH page on that site and I have used those images and text to update this site's Sloane Project ADH page in line with that. The Sloane Project is going from strength to strength. The steering group is immensely fortunate to have been guided by the expert chairmanship of Hugh Bishop succeeded two years ago by Professor Alastair Thompson with fantastic support from the NHS Breast Screening Programme. We are well advanced in consolidating our data and are about to publish some very interesting results on recurrences.



Background, aims & optimum viewing:


Aims

An easily accessible entry point to the understanding of the pathology of breast diseases
Uses the flexibility of the web to allow rapid updating

Target
Audience

Trainees in breast pathology
Teachers seeking educational material
The wider public

Features

Cross-specialty topics such as immunohistochemistry and specimen handling protocols
Very richly illustrated with 'mouse-over' features on many illustrations
Extensive hyperlinking throughout site - easily navigable

Optimal
Viewing

Internet Explorer 5.0 and above, Microsoft Edge, Firefox 1.5 and above or Opera 56.0.3051.104 with backwards compatibility.
Screen resolution of 1280x800
Broadband internet connection

Directions  

An evolving resource to cover all main areas of breast pathology
Developing links with other educational sites
Providing topical information
Developing interactive functionality

The
Author

Dr Jeremy Thomas, Formerly Lead Consultant Pathologist, Edinburgh Breast Unit

Summary of topics covered on this site:


Practice

Specimen handling; BMS Trimming;
Reporting protocols; Communication;
Microcalcification;
Links to screening documents;

Investigations   

Immunohistochemistry; Genetics

Benign &
Atypical

Epithelial proliferations - typical and atypical;
Fibroadenomas and related lesions;
Sclerosing lesions; Inflammations; Fibromatosis

Malignant
Disease

Carcinoma in situ;
Common and uncommon cancers;
Grading and staging breast cancer;
Prognosis of breast cancer


It is emphasised that these pages are complementary to the many excellent texts and aids available to the student of breast pathology. The author recommends the following references as a starting point:


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Site last updated 08/12/2018