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See also general practice points, malignant microcalcification (2) and benign microcalcification parts 1 & 2


DCIS


Calcification in DCIS:


Mammogram - linear calcification typical of DCIS
Mammogram - cluster of microcalcs (red arrow) typical of high grade comedo DCIS - Courtesy of Jim Walsh & Pat Forrest

Mammogram - linear calcification typical of DCIS
Detail of mammogram above - linear calcification in DCIS - Courtesy of Jim Walsh & Pat Forrest

Intermediate grade DCIS and luminal microcalcs:


Intermediate grade DCIS and calcs - specimen x ray
Intermediate grade DCIS & luminal calcs - specimen X ray showing two guide wires and scattered calcs

Intermediate grade DCIS and calcs Intermediate grade DCIS and calcs Detail of luminal calc - intermediate grade DCIS
Intermediate grade DCIS & luminal calcs

High grade DCIS & calcs


High grade DCIS and calcs
High grade DCIS & luminal calcs
High grade DCIS and calcs
High grade DCIS & luminal calcs
Intracystic papillary carcinoma and calcs Intracystic papillary carcinoma and calcs
Core biopsy - fragments of intracystic papillary carcinoma (in situ) with luminal calcs
Intracystic papillary carcinoma and calcs - low power Intracystic papillary carcinoma - CK 5/6 stain (negative)
Core biopsy - intracystic papillary carcinoma - blue circle around shattered calc (left) and uniformly negative CK 5/6 (right)

LCIS


Florid LCIS & calcs


Florid or pleomorphic LCIS:


Florid LCIS and calcs
Florid LCIS & luminal calcs


Florid LCIS - specimen X ray
Specimen X ray excision biopsy with localising needle - florid LCIS
Florid LCIS and calcs
Florid LCIS - low power showing expansion of terminal ducts and lobules

Florid LCIS and calcs
Florid LCIS "A" = terminal duct with Pagetoid subepithelial spread of LCIS cells (arrow); "B" = area of acinar expansion ++ by LCIS cells


Florid LCIS - high power   LCIS - negative E cadherin immunostain
High power view of area of florid LCIS in lobules (left) and uniformly negative E cadherin (right)

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