HOME PAGE PRACTICE & PROTOCOLS INVESTIGATIONS BENIGN / BORDERLINE MALIGNANT CASE MATERIAL

Fibroadenoma variants


See also 'Fibroadenoma' - main page


Variant forms (all benign):




Juvenile Fibroadenoma




Biopsy of a juvenile fibroadenoma - note both stromal and epithelial hyperplasia
Low power view of a complex fibroadenoma - The fibroadenomatoid pattern is often difficult to grasp in core biopsies from these cases


Juvenile fibroadenoma - note both stromal and epithelial hyperplasia. The mitosis in the bottom right image is an infrequent finding in these cases
Low power view of a complex fibroadenoma - The fibroadenomatoid pattern id often difficult to grasp in core biopsies from these cases Further low power view of a fibroadenoma core biopsy
Medium power view of a juvenile fibroadenoma showing stromal hypercellularity and mild epithelial hyperplasia High power view of a juvenile fibroadenoma

See also Image of the Quarter 2015 No 5




Giant Fibroadenoma


The term 'Giant Fibroadenoma' lacks a consistent definition and is not a true histopathological or clinico-pathological entity. It has been used as synonymous with Juvenile Fibroadenoma by some writers but as simply a large/very large fibroadenoma with usual histology by others.



Complex Fibroadenoma






Core biopsy of a complex fibroadenoma - so named because of the superimposed benign fibrocystic-like changes on the background architecture of a fibroadenoma.
Low power view of a complex fibroadenoma - The fibroadenomatoid pattern id often difficult to grasp in core biopsies from these cases Further low power view of a fibroadenoma core biopsy
Further low power view of a fibroadenoma core biopsy Medium power view showing early csyst formation. Note low stromal cellularity


Tubular Adenoma






Excision biopsy of a tubular adenoma.
Whole mount slide scan of a tubular adenoma

Medium power view of a tubular adenoma. High power view of a tubular adenoma - note clearly visible luminal and basal (myoepithelial) epithelial layers



Excision biopsy of a tubular adenoma - example 2.
Low power image of a tubular adenoma

Medium power view of a tubular adenoma. High power view of a tubular adenoma - note clearly visible luminal and basal (myoepithelial) epithelial layers


Lactating Adenoma





Excision biopsy of a lactating adenoma.
Low power view of a lactating adenoma Further low power view of a lactating adenoma
Medium power view of a lactating adenoma - note cytoplasmic vacuolation and nuclear atypia High power view of a lactating adenoma - note striking nuclear atypia



FNA from a lactating adenoma. The rather messy background, irregularity of cell groups and cytological atypia could give rise to a mistaken suspicion of malignancy. Note cytoplasmic vacuolation.
Low power view FNA from a lactating adenoma

Medium power view of FNA from a lactating adenoma - note cytoplasmic vacuolation and nuclear atypia High power view of FNA from a lactating adenoma - note striking nuclear atypia


Lactating adenomas may uncommonly undergo infarction which, in the early phase, gives rise to enlargement of the lesion and may precipitate clinical presentation. The following images are from a core biopsy of such a lesion:



Core biopsy from an infarcted lactating adenoma. The infarcted area is on the left hand side of the picture
Low power view FNA from a lactating adenoma


Core biopsy from an infarcted lactating adenoma. Note the following areas:
A - Edge of infarcted central zone; B - Zone of haemosiderin-laden macrophages around periphery of infarct;
C- zone of peripheral fibrosis; D - Subcapsular viable adenoma showing lactational change; E - Peripheral fibrous 'capsule'
Low power view FNA from a lactating adenoma

Infarcted lactating adenoma:
Left hand image - interface between infarcted central zone and haemisiderin-laden macrophage zone Right hand image from left to right - peripheral fibrosis; subcapsular viable zone; 'capsule'.
Medium power view of FNA from a lactating adenoma - note cytoplasmic vacuolation and nuclear atypia High power view of FNA from a lactating adenoma - note striking nuclear atypia

Return to top of page