Immuno expression profiles for BRCA1 and BRCA2 assosciated breast cancers

Immuno expression profiles for BRCA1 and BRCA2 assosciated breast cancers


Differential expression profiles of BRCA1 (Lower left) vs BRCA2 (Upper right) tumors. The basal phenotype characterized by CK 5/6- and cyclin E-positivity and estrogen receptor, HER2-, and p27-negativity is observed in BRCA1 tumors. Red indicates positive expression, green indicates negative expression.



From:


Honrado E, Benítez J, Palacios J. The molecular pathology of hereditary breast cancer: genetic testing and therapeutic implications.
Modern Pathology 2005; 18:1305–1320. doi:10.1038/modpathol.3800453

With permission from The Nature Publishing Group.

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