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Core biopsy of breast - sponge artefact



The criss-cross pattern seen on this H&E is due to the biopsy being placed on a sponge and allowed to dry before putting into formalin fixative. The pattern imprints through the block and does not disappear on deeper sectioning.
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Breast core biopsy - sponge artefact


I am grateful to my colleague, Dr Marie O'Donnell, who pointed this out to me


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