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Image of the Month (2010-4)

Use of CK5/6 immunohistochemistry to investigate possible invasion in DCIS



1cm mass in left breast; clinical invasive cancer; core biopsy


DCIS



Medium power view showing area suspicious of invasion


DCIS


High power detail of above


DCIS


CK5/6 staining of focus of normal breast tissue showing positive staining of myoepithelial layer. This is an internal control and is the best way to judge the pattern of immunostaining elsewhere in the section.
DCIS



Area of unequivocal DCIS showing CK5/6 positive bounding layer


DCIS