HOME PAGE PRACTICE & PROTOCOLS INVESTIGATIONS BENIGN / BORDERLINE MALIGNANT CASE MATERIAL

Image of the Month (2011-1)



Salivary gland-like carcinoma - Adenoid cystic carcinoma variant



Clinical cancer in a 45 year old female - macroscopically approx 25mm - low power view (x4) of core biopsy

Salivary gland-like carcinoma - low power

Detail - from above. 'Mouse over' for further detail or more infiltrative area - top right hand corner of low power view above

Salivary gland-like carcinoma - low power


Main body of tumour showing focal intermediate to strong staining with ER and negative staining with PGR.


Note: classical adenoid cystics of the breast are ER and PGR negative.

Salivary gland-like carcinoma - er/pgr


Main body of tumour showing dual cell population with CK7 and P63 immunostains ('Mouse over')
Salivary gland-like carcinoma - ck7 and P63 immunostains showing dual cell population


Detail of more infiltrative area showin two populations of cells (CK14 positive) and 'Mouse-over', CK7 positive.
Salivary gland-like carcinoma - ck7 and ck14 immunostains showing dual cell population in more infiltrative area


This case raises three important points:

  1. If morphology suggests a special type of carcinoma it is worth pursuing further (with immuno if appropriate) because there may be prognostic implications.


  2. Because this represents a variant form of adenoid cystic carcinoma (designated salivary gland-like carcinoma on this occasion) a more guarded prognosis should be given.


  3. In view of the ER result in this case there is an argument for endocrine therapy - in classical adenoid cystics endocrine therapy is not normally offered because the tumours are ER negaive.



See also Special Types - Adenoid cystic carcinoma of the breast.

Return to top of this page

Image of the week index

Return to Home Page