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Image of the Quarter (2014-1)



A good example of low grade DCIS



50 year old woman - small screen-detected distortion of architecture - core biopsy.




The core shows low grade DCIS. 'Mouse-over' for closer view. Main features: very uniform single cell population; small round nuclei; minimal atypia, no mitoses, no comedo necrosis. The scale bar (top left) shows that the duct measures approximately 1mm in diameter.

Low grade DCIS



These closer view shows further illustrate the homogeneity of this low grade cell population. 'Mouse-over' for closer view.

Low grade DCIS


These views are of a CK14 immunostain showing a positive basal layer around the periphery of the duct and an absence of myoepithelial cells in the proliferating population - supporting a diagnosis of DCIS. 'Mouse-over' for further detail.

High grade DCIS with small foci of invasion



See also Uses of immunohistochemistry in the diagnosis of DCIS v invasion.

See also Use of CK5/6 immunostaining to investigate possible invasion in DCIS.

See also... Carcinoma in situ on this site.

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