Image of the Quarter (2014-4)
DCIS arising in a papilloma
Screener. Core biopsy confirmed DCIS. Background papillary lesion also noted.
This is a photomerged image (original magnification x1.25) showing a large papillary lesion close to the margin. Much of the lesion has been taken over by intermediate grade DCIS
but there are residual benign papillary structures (see below). The 'Mouse-over' CK14 image shows a residual myoepithelial population lining the duct and also at the base of the negative staining proliferation.
At the top right of the image the papillary lesion merges with solid pattern DCIS.
These closer views further show the duct lining thickened focally by hyperplastic epithelium (noted mixed CK14 positive/negative population here)
while the papilloma is taken over by DCIS with a residual benign basal population illustrated by the CK14 stain (mouse-over).
This is the DCIS at the top end of the duct seen on the low power view above. The 'Mouse-over' CK14 image shows a residual myoepithelial population lining the duct.
This shows part of the papillary lesion which is predominnatly colonised by DCIS. On the right there are some residual benign papillary structures.
The 'Mouse-over' CK14 image shows a residual myoepithelial population lining benign papillary fronds.
- This is an uncommon lesion but illustrates well the difference bewtween this colonising type process in contrast with the ab initio situation with intracystic (encysted) papillary carcinoma where no background residual myoepithelium is normally seen.
See also... Intracystic papillary carcinoma (1)
Intracystic papillary carcinoma (2) on this site.
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