Image of the Quarter (2015-2)
A difficult core biopsy
55 year old woman - calcs on screening mammogram - core biopsy.
The biopsy shows DCIS on the left and top right of the image and apparent invasion in the central area. Mouse-over for detail.
These further H&Es show further detail of the central area of this biopsy.
These views are of CK 14 immunostaining where the apparent invasive disease is in fact bounded by an intect myoepithelial layer and is therefore in situ ('Mouse-over').
This is a good example of DCIS with distorting sclerosis. A recent publication (Walters LL et al Histopathology 2015; 66: 565-576) indicates that when seen in a core biopsy it is associated with a high chance of invasion in the subsequent excision